Many medications and drugs that are prescribed for trichotillomania and other disorders related to neurotransmitter imbalance have their effects by manipulating the release or re-uptake of neurotransmitters in the brain. Stimulants, such as amphetamines (i.e., methamphetamine, “speed”, Adderall, Vyvanse, Dexedrine), methylphenidate (i.e., Ritalin, Concerta), norepinephrine-reuptake inhibitors (i.e., Strattera, Edronax), and norepinephrine-dopamine reuptake inhibitors (i.e., Wellbutrin, Zyman) exert their effects by increasing the activity of norepinephrine and/or dopamine in the brain by either blocking re-uptake or stimulating the release of the neurotransmitter.
Likewise, many anti-anxiety medications, sleep aids (i.e., Ambien, Lunesta) and other depressants, such as alcohol, barbiturates (i.e., phenobarbital, Fioricet), and benzodiazepines (i.e., Xanax, Klonopin, Valium, Lorazepam) work by facilitating GABA activity or inhibiting glutamate or catecholamine (i.e., dopamine, norepinephrine or epinephrine) activity. Other medications work on serotonin, such as selective serotonin reuptake inhibitors (i.e., Paxil, Prozac, Zoloft, Celexa, Lexapro and Luvox) which block the reuptake of serotonin back into the pre-synaptic nerve.
The problem with these medications and many others from a neurotransmitter point of view is that they are not doing anything to make more neurotransmitters; they are simply shuffling them around or tricking the body into thinking there is more neurotransmitter than there actually is. This can have at least two undesirable affects.
First, the body, being duped into thinking there is more neurotransmitter than there actually is, will increase the degradation (destruction) of more neurotransmitter, which will cause further depletion over time. This is often what happens when medications, such as anti-depressants ‘stop working’; at this point, there is not enough neurotransmitter left for the drug to shuffle around and the person is left more depleted than when they started. (Unfortunately, at this point, a person is usually prescribed more of a given mediation or another medication to try and help them feel better, when all that really happens is the underlying problem is made worse.)
However, there is a solution. Even though the underlying neuronal damage is not known to be reversible, long-term correction is possible with continued use of amino acid therapy to make up for the underlying damage.